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Annette Thompson, a chemical engineering PhD student, has received a 2025 National Science Foundation Graduate Research Fellowship, a prestigious award that recognizes and supports outstanding students in a wide variety of science-related disciplines. Thompson is co-advised by Associate Professor Jerome Fox and Professor Michael Shirts.

This year, the National Science Foundation awarded Graduate Research Fellowships to 12 �������� students, including five from the College of Engineering and Applied Science. Due to federal budget cuts, the program was reduced by 50 percent, with only 1,000 fellowships awarded nationwide compared to 2,000 last year.

Fellows receive a three-year annual stipend of $37,000 and full coverage of tuition, fees��and insurance, along with opportunities for international research and professional development that span five years.

What is your research focused on?

My research focuses on better understanding and redesigning the molecular “assembly lines” that cells use to make chemical building blocks, especially fatty acids.��These natural systems rely on helper proteins to guide molecules through a series of enzymatic steps, but how these enzymes selectively interact with their partners is still not well understood.

I use computer-based tools—like simulations that predict how molecules move and interact over time, and models that estimate how changes in enzyme levels and behavior impact final yield—to study these systems and identify engineering targets for controlling product outcomes. By combining computational methods with experimental collaboration, my work aims to help create new biotechnologies that can produce a wider range of useful chemicals more efficiently than nature can on its own.

What are potential applications of your work?

My research could lead to more sustainable ways to make everyday products like medicines and fuels, without relying on petroleum-based processes. By making enzyme systems more precise and efficient, we can lower costs and create cleaner, greener manufacturing processes.

What does receiving this award mean to you?

Receiving this award is a huge honor. The support will allow me the flexibility to expand my research into new biosynthetic pathways and organisms, and to develop faster and better tools for characterizing new systems. I am deeply grateful to my advisors, Dr. Jerome Fox and Dr. Michael Shirts, whose support and expertise have been instrumental in shaping this work and making these collaborations possible.